Organization and Control of Hippocampal Circuits

I am interested in the broad question of how inhibition is regulated in the nervous system. To answer the latter question, my lab studies the synaptic and cellular organization of GABAergic microcircuits in the healthy and epileptic hippocampus. We employ a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, 2P functional calcium imaging, AI-aided segmentation of behavior, and large-scale computational modeling methods using supercomputers.